More about the project ACRIBiS
ACRIBiS - Advancing Cardiovascular Risk Identification with Structured Clinical Documentation and Biosignal
Derived Phenotypes Synthesis
Under the coordination of the University Hospital Bonn (UKB), 15 research institutions in Germany are working on the “ACRIBiS” project to further develop risk assessment for cardiovascular diseases, which is very important for prevention, diagnosis and therapy.
ACRIBiS is a clinical use case of the Medical Informatics Initiative (MII) of the Federal Ministry of Education and Research (BMBF). In ACRIBiS, clinical information and biosignals, such as the electrocardiogram (ECG), are combined using modern IT procedures in order to better assess patient-specific risks of cardiovascular diseases.
This benefits patients in particular, as not only can prevention, diagnostics and therapy be better managed in this way, but individualized risk information is also made available to patients.
Goals of ACRIBiS
ACRIBiS focuses on the individual risk assessment of patients with cardiovascular diseases in order to improve their treatment and prevention.
Therefore, routine cardiological documentation is being structured and standardized across all sites, the infrastructure for the automated analysis of biosignal data, such as ECGs, is being expanded and integrated into the respective data integration center (DIC).
Six core sites and nine implementation sites are involved in the ACRIBiS project.The extension in the NUM-DIC project has brought in additional partners. The NUM-DIC project builds on the preliminary work of the Medical Informatics Initiative (MII), under which data integration centers (DIC) were set up at most German university hospitals to support data provision and cross-site data integration and analysis.
An ACRIBiS Intersectoral Interaction Forum (AIIF) is organized annually to which associated partners and networks that have committed to participate and provide input, as well as other interested parties, are invited.
The cross-sector consortium Digital Model Region Healthcare Tripoint (DMGD) and representatives of the General Practitioner Network North-Rhine Westphalia (NRW-GPRN) and Bavaria (BayFoNet) are associated partners.
Patient participation
Representatives of the most important patient organizations, namely the German Heart Foundation e.V. and the German Stroke Foundation, are important partners in the ACRIBiS-network. Both organizations are actively involved in the project as full members of the Scientific Advisory Board (SAB) and provide their expertise.
As part of the prospective follow-up of the patients in the ACRIBiS cohort, the patient-related results will also be taken into account. Possible recommendations of the proposed Module 3 Use Case Patient-Centered Health Outcomes Research within the Medical Informatics Initiative (PCOR-MII) will be taken to heart.
In addition, we ensure that patients' views are appropriately integrated in all work packages (WP). This is currently done in particular by consulting patients on the identification of relevant outcomes (WP2) and on the best ways to visualize individual risks (WP4). Finally, we will evaluate the acceptance and use of the developed risk communication tools for patients (WP6).
These measures ensure that the interests of patients and relevant stakeholders are adequately considered in terms of their needs, concerns and preferences throughout the course of the project.
The ACRIBiS work plan is divided into seven work packages (WPs).
The overall coordination and administration is carried out in WP1, while the decentralized activities carried out by all partners (e.g. patient recruitment for the ACRIBiS cohort) are summarized in WP7.
The core development work will be carried out in WP2, WP3 and WP4, with the contributions from WP2 (structured clinical data) and WP3 (results of biosignal analysis) feeding into risk prediction, which forms the core of ACRIBiS in WP4.
WP5 deals with regulatory issues and data security, while WP6 implements the evaluation plan and provides a comprehensive evaluation concept to assess the expected impact of the implementation.
To support the project lead, a project management team (PMT) was set up in WP1 under the direction of the ACRIBiS network coordinator. The PMT is in contact with the OCB and the local management of the participating sites. It supports communication throughout the project and is responsible for project monitoring and reporting.
WP2 focuses on the development of a structured and standardized, syntactically and semantically fully interoperable documentation of a consensus-based core dataset of routine cardiovascular data to improve cardiovascular risk stratification and prediction.
AP3 realizes the integration of ECG data from different sources into interoperable
databases to enable location- and device-independent analysis for biosignal-based risk
risk prediction independent of location and device.
WP4 is responsible for providing reference data and reference software for risk prediction algorithms. In addition, the implemented risk prediction models and predictions are visualized.
Biosignals represent a special data source with very individualized bio-information. Therefore, WP5 focuses in particular on the use and, if necessary, supplementation of the broad consent and data security of the biosignal data.
WP6 provides a comprehensive evaluation concept to assess the expected impact of the implementation of the various elements of the ACRIBiS network.
WP7 realizes the dissemination of ACRIBiS results at all partner sites in order to
achieve the following goals:
1. harmonized implementation of structured clinical documentation at all sites.
2. implementation of biosignal acquisition and processing capabilities at all sites.
3. recruitment, informed consent and documentation of the ACRIBiS cohort.
Important downloads
for patients
Here you will find current information on the ACRIBiS study.
Graduate biologist, Scientific Project Coordinator
Master in Physics, Assistant physician for Anesthesiology and Operative Intensive Care Medicine, Medical employee of the MWTek staff unit
Specialist in Internal Medicine, Further Training in Medical Informatics
Graduate Computer Scientist, Research Assistant Software Development
Master of Science in Computer Science, Research Assistant Software Development
Graduate Business Economist, Project Manager
Specialist in Internal Medicine and Cardiology, Medical Clinic II for Cardiology, Angiology, Pneumology and Internal Intensive Care Medicine
Institute for Digital Medicine
Marko Jovanović
Research Associate
Laura Bresser
Research Associate
Gereon Risse
Non-scientific staff
Contact
ACRIBiS Project Management Bonn
If you have any questions, please do not hesitate to contact Project Management (acribis@ukbonn.de).
Dr. Carina A. Peter (née Beuck)
Visitor address
University of Bonn
Venusberg-Campus 1, building 33
ACRIBiS on LinkedIn
Follow the progress of ACRIBiS, a project of the Medical Informatics Initiative (MII), on LinkedIn
ACRIBiS-Newsletter 💌
Stay up to date with the MII internal ACRIBiS-Newsletter: To register, please send a blank e-mail with the subject “Subscribe to ACRIBiS-Newsletter” to: acribis@ukbonn.de
ACRIBiS Project Management Hannover
Dr. Alexandra CieslakPhone: +49 511 532 34121
E-Mail: acribis@mh-hannover.de
